| abstract |
The present invention relates to a nanocomposite, a pharmaceutical composition containing the same, a drug delivery system, and a drug delivery method. The nanocomposite of the present invention is composed of a nucleic acid molecule, a monovalent cationic drug and a biocompatible polymer surfactant, and has a hydrodynamic size of 10 nm or less and is uniformly distributed in a colloidal form in an aqueous environment. In addition, the nanoscale colloidal formulations of the present invention can protect nucleic acid molecules from nuclease agents (e.g., serum nucleases) enriched in physiological environment through the formation of stable single complexes, Can provide additional protection of nucleic acid molecules by micellar passivation as well as improved permeation and in vivo transport. Accordingly, the nanocomposite of the present invention and the composition and system comprising the nanocomposite of the present invention can stably transport the active ingredient (for example, a nucleic acid molecule and a monovalent cationic drug) to a target cell / tissue, , Can be effectively applied to the treatment or detection of cancer). |