| abstract |
The present invention provides functionalized polypeptides, particularly therapeutic polypeptides (e. G., ScFv). The polypeptides of the present invention can be used as linkers that can be rapidly and specifically functionalized by the addition of one or more functional moieties (e.g., PEG) and / or binding specificities (e. G., Amino acid sequences with specific binding specificities) Sequence. Such functionalized polypeptides are advantageous in that they have improved pharmacokinetic properties (for example, improved in vivo half-life, tissue penetration and tissue residence time) over non-functionalized polypeptides. A method for producing a functionalized polypeptide that is rapidly and reproducibly also provided. |