http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101705412-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-277 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 |
| filingDate | 2014-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101705412-B1 |
| titleOfInvention | Composition for preventing or treating immune disease comprising mesenchymal stem cell treated stat3 inhibitor |
| abstract | TECHNICAL FIELD The present invention relates to a cell therapy composition for preventing or treating immune diseases, which comprises mesenchymal stem cells treated with STAT3 inhibitor as an active ingredient. The STAT3 inhibitor-treated mesenchymal stem cells according to the present invention can effectively inhibit the expression and production of inflammatory cytokines and inflammatory factors in mesenchymal stem cells, and when co-cultured with undifferentiated T cells under pathological conditions, T cells Of the present invention has the effect of inhibiting the differentiation into cytotoxic Th17 and Th1 cells and enhancing the differentiation and activity of immunoregulatory T cells (Treg) having the property of suppressing the function of abnormally activated immune cells and controlling the inflammatory response The effect is excellent. Therefore, the mesenchymal stem cells treated with the STAT3 inhibitor can be used as a cell therapy composition composition capable of preventing or treating immune diseases such as autoimmune diseases, inflammatory diseases and graft rejection diseases caused by abnormal regulation of various immune responses. |
| priorityDate | 2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 476.