| abstract |
The present invention provides a N1-N5-substituted biaguanide derivative represented by the following formula (1), a pharmaceutically acceptable salt thereof, a process for producing the same, and a pharmaceutical composition containing the same as an active ingredient. The biguanide derivatives of the present invention exhibit the AMPKa activation effect and the cancer cell proliferation inhibitory effect which are superior to the conventional drugs in a smaller amount than those of the conventional drugs and are useful for the prevention of diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, Syndrome, cancer, and the like. [Chemical Formula 1] |