| abstract |
(I) [Wherein, A represents a C3~C12 cycloalkyl group that may be substituted with one to three pieces selected from fluoro group, a hydroxyl group, C1~C6 alkyl group, R 1, R 2 and R 3 each independently represents a hydrogen atom, R 4 represents a hydrogen atom or a prodrug group, Y represents -CH 2 -CHR 5 -CH 2 -NHR 6 (wherein R 5 represents a hydrogen atom, a C 1 -C 6 alkyl group or a C 1 -C 6 alkyl group) represents a C1~C6 alkoxy group, R 6 represents a hydrogen atom or a prodrug thereof), etc. represents a] representing a compound, or its pharmacologically acceptable salts is brought TAFIa enzyme inhibitory activity, myocardial infarction, angina pectoris, acute pipe syndrome that , Cerebral infarction, deep vein thrombosis, pulmonary embolism and the like. |