| abstract |
The present invention relates to an FK506 derivative having no immunosuppressive activity and retaining neuronal regeneration activity, a method for producing the same, and a pharmaceutical composition for preventing or treating a neurological disease, which comprises 9-deoxo-prolyl-FK506, 31-O -Dimethyl-FK506, or 9-deoxo-31-O-dimethyl FK506 can accelerate nerve regeneration and lack immunosuppressive activity, which can reduce side effects in the treatment of neurological diseases. |