| abstract |
The present invention provides 2,5-disubstituted aryl sulfonamide CCR3 antagonists of formula I, Ia or II and pharmaceutical compositions thereof: Ia I II Wherein X, Y, Z and R 1 to R 5 are as defined in the specification. The invention also provides methods of using the same to treat, prevent or alleviate one or more symptoms of a CCR3-mediated disorder, disease or condition. |