| abstract |
In one aspect, the invention provides a compound of formula I; Wherein the variables X 1a , X 1b , X 1c , X 1d , Q, A, R 1 , B, L, E and the subscripts m and n have the definitions described herein. In yet another aspect, the invention provides pharmaceutical compositions, as well as Bcl-2, wherein comprising a compound of formula I - characterized by the expression or overexpression of the apoptosis St. Bcl-x L protein-apoptotic proteins, e.g., wherein Methods of using compounds of formula I for the treatment of diseases and conditions (e.g., cancer, thrombocytosis, etc.). |