| abstract |
The present invention relates to an ethynyl derivative of formula (I), or a pharmaceutically acceptable acid addition salt thereof, a racemic mixture, or a corresponding enantiomer and / or optical isomer and / or stereoisomer thereof: (I) In this formula, Y is N or CH; R < 1 > is fluoro or chloro; R 2 is hydrogen or methyl. Surprisingly, it has now surprisingly been found that the compounds of formula I according to the invention are useful as metabotropic glutamate receptor antagonists for the treatment of anxiety, pain, depression, fragile X syndrome, autism spectrum disorders, Parkinson's disease or gastroesophageal reflux disease (GERD) Allosteric modulators). |