| abstract |
The present invention relates to the stable purification of a 4,5-epoxy morphinan derivative or a pharmacologically acceptable acid addition salt thereof. That is, the tablets of the present invention contain (1) a specific 4,5-epoxy morphinan derivative or a pharmacologically acceptable acid addition salt thereof as an active ingredient, (2) sodium thiosulfate, (3) a sugar and a sugar alcohol (4) crospovidone, carboxymethyl starch sodium or a mixture thereof, and the content of (4) is 1 to 20% by weight per unit weight of the unit containing the active ingredient. |