| abstract |
FIELD OF THE INVENTION The present invention relates generally to alkynes containing drugs, and in particular to phenylethynyl-thiophenes based on metalloprotease inhibitor compounds. More specifically, the present invention provides novel MMP inhibitory compounds that exhibit increased efficacy, stability of the metabolic stability and / or reduced toxicity with respect to currently known MMP inhibitors for the treatment of other diseases such as pain and cancer. The invention also relates to a method of treating a patient ' s pain comprising administering to the patient an effective amount of the present compound to reduce pain. |