http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101672554-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B65D2501-0036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B65D1-0223 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101672554-B1 |
| titleOfInvention | Soluble fragments of influenza virus PB2 protein capable of binding RNA-CAP |
| abstract | The present invention relates to a soluble fragment of influenza virus RNA-dependent RNA polymerase subunit PB2 and variants thereof, and to a crystallized complex thereof comprising an RNA cap analogue. The present invention also relates to a computerized method of screening and designing compounds that interact with RNA cap binding pocket using the structural coordinates of the complex. In addition, the present invention preferably binds to a PB2 polypeptide fragment comprising an RNA cap binding pocket by using the PB2 polypeptide fragment in a high-speed setting, and preferably inhibits interaction with an RNA cap or an analogue thereof To a method for identifying a compound. The present invention also relates to a compound for treating a disease state due to a viral infection caused by a negative-sense single strand RNA virus, and a pharmaceutical composition comprising the identified compound. |
| priorityDate | 2007-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1370.