abstract |
The present invention provides humanized antibodies that immunospecifically recognize human < RTI ID = 0.0 > a9 < / RTI > integrins. Some of the antibodies may inhibit the biological function of the alpha 9 integrin and thereby inhibit the proliferation or metastasis of cancer, such as cancer cells, and inflammatory diseases such as rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes mellitus, , Multiple sclerosis, granuloma, inflammatory bowel disease (ulcerative colitis and Crohn's disease), autoimmune disease, and the like. |