http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101656966-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-22 |
| filingDate | 2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101656966-B1 |
| titleOfInvention | Ethynyl derivatives as metabotropic glutamate receptor modulators |
| abstract | The present invention relates to ethynyl derivatives of formula (I) or pharmaceutically acceptable acid addition salts thereof, racemic mixtures, or the corresponding enantiomers and / or optical isomers and / or stereoisomers thereof: (I) In this formula, Y is N or CH, provided that when at least one of U, V, or W is N, Y may be CH only; U is N or CR < 4 >; V and W are independently N or CH provided that, U, V or W only one of which is at the same time may be nitrogen, R 4 is hydrogen, methyl or halogen; R < 1 > is phenyl or heteroaryl and is optionally substituted with halogen, lower alkyl or lower alkoxy; R is hydrogen or lower alkyl; R 2 is hydrogen, lower alkyl, lower alkoxy, CF 3 or S-lower alkyl; R 3 and R 3 ' are, independently of each other, hydrogen, lower alkyl or lower alkoxy, R 3 and R 3 ' together form a C 3 -5 -cycloalkyl-, tetrahydrofuran- or oxetane-ring. It has been found that the compound of formula I is an allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5). |
| priorityDate | 2011-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 206.