http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101656388-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-603 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-604 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074 |
| filingDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101656388-B1 |
| titleOfInvention | A metabolites for the generation, maintenance, prolonged undifferentiated growth of pluripotent stem cells, composition comprising the same and method of culturing pluripotent stem cell using the same |
| abstract | According to the present invention, when nicotinamide is added to the step of inducing differentiation induction to produce pluripotent stem cells in human differentiated cells, it is possible not only to improve the efficiency of dedifferentiation induction, Can be reduced. Nicotinamide has been shown to effectively reverse the differentiation inducing culture conditions by inhibiting aging induction and oxidative stress during induction of differentiation and inducing cell proliferation and mitochondrial activity enhancement. INDUSTRIAL APPLICABILITY The present invention contributes to optimization of the production process of induced pluripotent stem cells derived from a small amount of patient-specific somatic cells obtained from various sources, thereby drastically improving the development of a personalized stem cell therapeutic agent for clinical application and development of a new drug, It will contribute to speeding up the time. According to another aspect of the present invention, nicotinamide can be a culture medium composition effective for maintaining undifferentiated states of human embryonic stem cells and human induced pluripotent stem cells, which are representative pluripotent stem cells, using nutrition cells and serum Were identified under defined culture conditions. The present invention is expected to be useful for developing a high-performance human pluripotent stem cell mass culture system required for the industrialization of human pluripotent stem cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10131881-B2 |
| priorityDate | 2012-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 509.