| abstract |
Described herein are compounds of formula I and pharmaceutically acceptable salts and esters thereof. The compounds of formula I have utility as tissue-selective androgen receptor modulators (SARMs) and are particularly useful as agents in the treatment of prostate cancer and other AR-dependent conditions and diseases in which AR antagonism is required. Formula I In the above formula (I) R 1 to R 16 , A, B and E are as defined in the claims. |