http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101654466-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87d40fb4785f5b3f1a4dba8c69339d1a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 |
| filingDate | 2015-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4ae9e2d7d512e1bf504da2ca32fb982 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e170ac347ef3ed58d11444a1c4576a5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc96434b5a4e061451c4db0c0cd3882b |
| publicationDate | 2016-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101654466-B1 |
| titleOfInvention | Composition for preventing or treating cancer comprising Cathepsin S inhibitor and TRAIL |
| abstract | The present invention relates to a pharmaceutical composition and a pharmaceutical composition for enhancing anti-cancer effects, comprising a cathepsin S inhibitor, which can overcome TRAIL resistance, and to a method for promoting cancer cell death. When Z-FL-COCHO, which is a cathepsin S inhibitor, and TRAIL are concomitantly administered to any one of cancer cells among kidney cancer, breast cancer and glioma, the differentiation of Poly(ADP-Ribose)Polymerase (PARP) increases, Bcl-2 and c-FLIP(L), which is an inhibitor of apoptosis protein (IAP) decreases, and TRAIL-induced apoptosis of cancer cells increases. Thus, the compositions of the present invention can be beneficially used for preventing or treating kidney cancer, breast cancer and glioma. |
| priorityDate | 2015-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 173.