| abstract |
The compounds of the general formula (I) or their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs can be administered orally for the treatment of allergic diseases and conditions such as asthma, allergic rhinitis and atopic dermatitis useful: In the above general formula (I) W is chloro or fluoro; R 1 is halo, -CN, -C 1 -C 6 alkyl, -SOR 3, -SO 2 N ( R 2) 2, -N (R 2) 2, NR 2 C (O) R 3, -CO 2 R 2, -CONR 2 R 3, -NO 2, -OR 2, -SR 2, -O (CH 2) p OR 2 , and -O (CH 2) p O ( CH 2) q OR 2 and, here Each R 2 is independently hydrogen, -C 1 -C 6 alkyl, -C 3 -C 8 cycloalkyl, aryl, or heteroaryl; Each R 3 is independently -C 1 -C 6 alkyl, -C 3 -C 8 cyclo alkyl, aryl or heteroaryl; p and q are each independently an integer of 1 to 3; |