| abstract |
The present invention provides a composition of formula 1: [Chemical Formula 1] [FGF21-first connector] - [Ab] - [second connector -Ex4] In this formula, FGF21 is an FGF21 homolog; Ex4 is an exendin 4 homologue; Ab is an aldolase catalytic antibody or antigen binding portion thereof; The first linker is covalently attached to the side chain of the protein-linking moiety and the binding site of the antibody in FGF21; The second linker is covalently attached to the side chain of the peptide-linked residue and the binding site of the antibody in Ex4, The first and second connectors may be the same or different. Diabetes, or diabetes. ≪ Desc / Clms Page number 2 > |