http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101640161-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 |
| filingDate | 2008-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101640161-B1 |
| titleOfInvention | 6,7-dialkoxy quinazoline derivatives useful for treatment of cancer related disorders |
| abstract | In view of the infinite possibilities provided by quinazoline compounds, the present inventors have undertaken the synthesis and screening of a number of novel compounds with novel structural features. As a result, it has been surprisingly found that the quinazoline having a 3-ethynyl anilino group at position 4 and specifically having an alkoxy group substituted at positions 6 and 7 is more potent than the other known quinazoline drugs And have specific antiproliferative properties. Furthermore, surprisingly, the compounds according to the invention are significantly less toxic, and this safety profile is very advantageous in the therapeutic field. The novel compounds described in the present invention can be represented by the general structural formula (I) and have not been synthesized so far, and the usefulness and safety profile in the therapeutic field have not been disclosed. (A) structure, compound I is NRC-2694. |
| priorityDate | 2008-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.