| abstract |
The present invention provides a compound of formula (II): < EMI ID = 2.1 > These compounds are selective EP4 inhibitors and are useful in the treatment of inflammatory conditions such as arthritis. ≪ In this formula, A is , , or ego; R 1 is CH 3 , CF 3 or F; R 2 is H, CH 3 or F; R 3 is CH 3 , OCH 3 , OH, F; R 4 is OH or CH 2 OH; X is CH or N; |