| abstract |
The present invention relates to the use of one or more compounds comprising the following amino acid sequences for the manufacture of a medicament for the prevention and / or treatment of sickle cell disease: (Formula 1), Wherein X 1 is any amino acid residue, X 2 is an amino acid residue selected from the group consisting of aspartic acid (D) and glutamic acid (E), X 3 is any amino acid residue, X 4 is any amino acid residue moiety, X 5 is proline is an amino acid residue selected from the group consisting of (P) and alanine (a), X 6 is an amino acid residue selected from the group consisting of aspartic acid (D) and glutamic acid (E), X 7 is any Wherein n and m are independently integers greater than or equal to 0 and wherein the amino acid sequence according to Formula 1 is not identical to or does not comprise an 8-mer polypeptide fragment of alpha-synuclein with the amino acid sequence DMPVDPDN And the compound has the ability to bind to an antibody specific for an epitope of alpha-synuclein comprising the amino acid sequence DMPVDPDN. |