| abstract |
The present invention provides methods of modulating, e. G., Antagonizing, and treating hedgehog-related disorders such as cancer (e. G., Hydrobromycin) in the activity of the hedgehog signaling pathway. In particular, the present invention relates to the use of a compound of formula (I), a compound of formula (II) or a compound of formula (III), or any compound enumerated or incorporated herein by reference) and a cholesterol biosynthesis pathway inhibitor Abnormal growth due to phenotypes such as Ptch dysfunction, hedgehog function acquisition, spindle function acquisition or Gli function acquisition by administering to a mammal a combination of an anti-angiogenic agent, a Gli inhibitor and / or a phosphatidylinositol 3-kinase (PI3K) A method for suppressing a state is provided. |