http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101595747-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-68 |
| filingDate | 2014-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101595747-B1 |
| titleOfInvention | Method for preparing of nafamostat mesilate |
| abstract | A naphamostat mesylate used as a blood coagulation inhibitor is not only obtained in high purity but also a naphamostat mesylate having a high purity and capable of uniformly producing naphamostat mesylate in crystalline form III is disclosed do. The process for preparing the naphamostat mesylate comprises the steps of: (a) reacting 4-guanidinobenzoic acid hydrochloride and 6-amidino-2-naphthol methanesulfonate in the presence of N, N'-diisopropylcarbodiimide Lt; RTI ID = 0.0 > 1 < / RTI > (b) adding the compound of formula 1 to a solvent mixed with water (H 2 O) and saturated aqueous sodium hydroxide (NaHCO 3 ) to produce a compound of formula 2; And (c) adding the compound of Formula 2 to the solvent followed by addition of methanesulfonic acid to prepare a naphamostat mesylate compound of Formula 3 below. [Structural formula 1] [Structural formula 2] [Structural Formula 3] |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102314436-B1 |
| priorityDate | 2014-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.