http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101593262-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2875 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 2010-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101593262-B1 |
| titleOfInvention | Sequence dependent aggregation |
| abstract | A method for reducing the aggregation of an immunoglobulin in solution comprising the steps of: i) comparing the amino acid sequence of the fourth backbone region of the heavy chain of the antibody to a baseline or germline sequence and comparing one or more threonine residues and / Determining whether the serine residue is replaced by another amino acid residue, and ii) modifying the amino acid sequence of the immunoglobulin by returning the exchanged threonine residue and / or serine residue back to the threonine or serine of the reference or germline sequence , Thereby reducing aggregation of the immunoglobulin in solution. |
| priorityDate | 2009-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 314.