| abstract |
A dual release oral administration system / dosage form comprising an immediate release component / composition and a delayed release component / composition is described. Each immediate release component / composition and delayed release component / composition may comprise one or more of the following: a homologue of one or more homologous amines, their analogs, their derivatives, their prodrugs, their metabolites and / or their salts and one or more pyridoxines, Salts, metabolites thereof and / or salts of metabolites. The dual-release oral administration system / dosage form exhibits an improved pharmacokinetic profile compared to the current Diclectin (R) formulation, for example, for the relief of nausea and vomiting symptoms, such as nausea during pregnancy and nausea (NVP) useful. |