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filingDate 2014-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2015-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-101566345-B1
titleOfInvention A method to improve the tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting
abstract The present invention relates to a method for improving cancer diagnostic efficiency by controlling the ratio of the inner surface functionality of a multivalent ligand to a cancer target ligand moiety and a multivalent ligand for cancer diagnosis, According to the method of the present invention, by controlling the ratio of the internal surface functional group of the multivalent ligand to the cancer-targeting ligand moiety, Binding to receptors results in the aggregation of other homologous receptors around the bound receptors, leading to a more favorable chance of multivalent binding to receptors in which other ligand units that have not participated in binding are assembled In which the bound ligand units result in a properly selected type of internal It has an effect of remarkably improving avidity in which the surface functional group interacts with the surface of cancer cells at the same time in addition to the receptors in which the ligand units not participating in the binding are assembled.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101911472-B1
priorityDate 2014-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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