| abstract |
The present invention is based on the discovery that a motif consisting of an amino acid or peptide comprising one or more cysteine residues is attached to the end of the parent antibody, particularly to the heavy chain end, to a modified antibody-drug conjugate (mADC, Antibody-Drug Conjugate) and a method for producing the antibody or modified antibody-drug conjugate. The modified antibody-drug conjugate (mADC, Antibody-Drug Conjugate) according to the present invention can accurately deliver the drug to the target cell due to high specificity of the antibody of the conjugate contained in the antigen, Despite the effects, it is possible to improve the utilization of drugs with limited use due to toxicity, especially anti-cancer drugs. The present invention also relates to a composition for the treatment of diseases, particularly cancer, using the modified antibody-drug conjugate. |