| abstract |
The present invention relates, at least in part, to substituted tetracycline compounds of formula (I) These tetracycline compounds can be used in the treatment of various tetracycline compound-related conditions, such as bacterial infections and neoplasms.n n n (I)n n n n n n n n Wherein X is CHC (R 13 Y'Y), CR 6 ' R 6 , C = CR 6' R 6 , S, NR 6 or O; E is NR 7d R 7e , OR 7f or (CH 2 ) 0-1 C (= W ') WR 7g ; W is O, S, NR 7h or CR 7i R 7j ; W 'is O, S or NR 7k .n n n Substituted tetracycline compounds, bacterial infections, neoplasms, cancer |