| abstract |
The present invention belongs to the fields of cell biology, immunology and oncology. Specifically, the present invention relates to a humanized antibody recognizing an alpha v [ beta] 6 integrin comprising at least a part of a non-human-derived variable region and a human-derived immunoglobulin. The present invention also relates to a method of treating various diseases by administering the pharmaceutical composition, and a humanized anti--α β ν 6 antibody comprising method for producing the antibody, this. The present invention is a ligand that binds to the use of such differentially expressed in the measurement of 'history' of the verification of the differential expression of the integrin α ν β 6 on the surface of tumor cells and tissues, tumor cells, and integrin α ν β 6 , Particularly a method for diagnosis and treatment / prevention of tumor metastasis using an antibody and a method for removing residual metastatic tumor cells. |