abstract |
Disclosed herein are isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to Glypican-3 with high affinity. Methods of expressing nucleic acid molecules, expression vectors, host cells and glypicane-3 antibodies encoding glypicane-3 antibodies are also disclosed. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising a glypicane-3 antibody are also disclosed. A method of detecting glypicane-3, and methods of treating various glypicane-3-related disorders, including hepatocellular cancer, are disclosed. |