abstract |
The present invention relates to an agonist antibody that specifically binds to Notch3 and activates signal transduction. The invention includes an antibody that binds to an epitope comprising the first Lin12 domain. The invention also encompasses the use of these antibodies to treat or prevent a Notch3 related disease or disorder.n n n n Anti-Notch3 agonist antibody, Notch3 related disease, Notch3-mediated signal transduction, degenerative disease |