| abstract |
The present invention relates to a method of treating or preventing an autoimmune disease such as systemic lupus erythematosus (SLE), myasthenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiple sclerosis, Sjogren's syndrome and autoimmune hemolytic anemia Treatment of allergic diseases including general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disease, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, dermatoses with inflammatory elements, chronic inflammatory diseases, all forms of hypersensitivity Substituted bicyclic heteroaryl and compositions containing same. The present invention also relates to a method of treating leukemia, such as acute myelogenous leukemia (AML), bone marrow dysplasia syndrome (MDS), myeloproliferative disease (MPD), chronic myelogenous leukemia (CML), T-cell acute lymphoblastic leukemia But are not limited to, B-cell acute lymphoblastic leukemia (B-ALL), non-Hodgkin's lymphoma (NHL), B-cell lymphoma, and solid tumors such as breast cancer. Lt; RTI ID = 0.0 > and / or < / RTI > cancer associated therewith.n n n Phosphatidylinositol 3-kinase, autoimmune disease, rheumatoid arthritis, leukemia |