http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101501576-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-74 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2010-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101501576-B1 |
| titleOfInvention | Aryloxyphenoxyacetyl-based compound having HIF-1 inhibition activity, preparation method thereof and pharmaceutical composition containing the same as an active ingredient |
| abstract | The present invention relates to a compound inhibiting HIF-1 activity, a process for producing the same, and a pharmaceutical composition containing the compound as an active ingredient. The compound according to the present invention exhibits anticancer activity by inhibiting the activity of HIF-1, a transcription factor that plays an important role in the growth and metastasis of cancer cells, rather than exhibiting anticancer activity by non-selective cytotoxicity. Accordingly, the compound of the present invention or a pharmaceutically acceptable salt thereof inhibits HIF-1 activity and can be used as a therapeutic agent for various solid cancer diseases such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound of the present invention or a pharmaceutically acceptable salt thereof can be used as an active ingredient of a therapeutic agent for diabetic retinopathy or arthritis which is exacerbated by increased expression of VEGFA by HIF-1 in a hypoxic state. |
| priorityDate | 2010-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 380.