http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101493444-B1

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filingDate 2014-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2015-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-101493444-B1
titleOfInvention Polycaprolactone nano-fibers comprising physiological active substance and manufacturing method thereof
abstract Disclosed is a polycaprolactone nanofiber containing a physiologically active substance and a method for producing the same. The method for producing a polycaprolactone nanofiber containing a physiologically active substance according to the present invention comprises: 5 to 30 parts by weight of polycaprolactone and 0.5 to 10 parts by weight of Poloxamer, based on 100 parts by weight of the first solvent, To prepare a first solution; 0.5 to 5 parts by weight of sodium alginate based on 100 parts by weight of the second solvent and dissolving the physiologically active substance to prepare a second solution; Mixing and stirring the first solution and the second solution to prepare an emulsion solution in which the second solution is dispersed in the first solution; And electrospinning the emulsion solution to produce nanofibers. According to the present invention, the physiologically active substance can be contained in the nanofiber by a simple process through a single electrospinning, the denaturation of the physiologically active substance can be minimized, The release rate of the active material can be controlled in various ways.
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Total number of triples: 37.