| abstract |
The present invention relates to the identification of a microRNA, miR-208, which induces expression of? -Myosin heavy chain (? -MHC) and inhibits a fast skeletal muscle contraction protein gene. Inhibition of this function is suggested for the treatment of cardiomyopathy, cardiac hypertrophy and / or heart failure, and this increase in function can be used to inhibit slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.n n n n MicroRNA, β-myosin heavy chain, cardiac hypertrophy, heart failure |