| abstract |
It is an object of the present invention to provide a pharmaceutical preparation containing an improved antibody molecule. The present invention modifies the amino acid sequence of the variable region and the normal region of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to improve the pharmacokinetics while enhancing antigen neutralization ability, And also to improve the immunogenicity, safety and physical properties (stability and uniformity), and to provide a pharmaceutical preparation containing a second generation molecule superior to TOCILIZUMAB. The preparation contains arginine, preferably as a stabilizer, and is provided in liquid or solid form. |