abstract |
The present invention provides a monoclonal antibody that binds to the N-terminus of human hepcidin-25 and has high affinity and selectivity for the polypeptide. The antibodies of the present invention are useful for increasing serum iron levels, reticulocyte count, erythrocyte count, hemoglobin, and / or hematocrit, and treating various diseases such as anemia in human subjects in humans. The antibodies of the invention are also useful as analytical tools, for example in sandwich ELISAs. |