| abstract |
The present invention relates to compounds of formula (I) wherein R < 1 > In this formula, R is hydrogen or lower alkyl; R 1 is - (CH 2) n - ( O) o - , and heterocycloalkyl, wherein the heterocycloalkyl group optionally, lower alkyl, hydroxy, halogen or - heterocycloalkyl or -C (O) (CH 2 ) p -aryl; n is 0, 1 or 2; o is 0 or 1; p is 0, 1 or 2; R 2 is CF 3 ; Optionally substituted lower alkoxy- or halogen-substituted cycloalkyl; Indan-2-yl; Optionally heteroaryl-substituted heterocycloalkyl; Or aryl or heteroaryl, Wherein the aromatic ring is optionally, lower alkyl, halogen, heteroaryl, hydroxy, CF 3, OCF 3, OCH 2 CF 3, OCH 2 - cycloalkyl, OCH 2 C (CH 2 OH ) (CH 2 Cl) (CH 3), S- lower alkyl, lower alkoxy, CH 2 - lower alkoxy, lower alkynyl, cyano, -C (O) - phenyl, -O- phenyl, -O-CH 2 - phenyl, phenyl and -CH 2 - phenyl, wherein the phenyl ring is optionally substituted with one or more substituents independently selected from the group consisting of halogen, -C (O) -lower alkyl, -C (O) OH or -C ≪ / RTI > The aromatic ring is optionally substituted with heterocycloalkyl, OCH 2 -oxetan-3-yl, or optionally lower alkyl-substituted O-tetrahydropyran-4-yl; X is a bond, -NR'-, -CH 2 NH-, -CHR '' -, - (CHR '') q -O-, -O- (CHR '') q - or - (CH 2) 2 - ego; Y is a bond or -CH 2 - and; R ' is hydrogen or lower alkyl; R '' is hydrogen, lower alkyl, CF 3, lower alkoxy; q is 0, 1, 2 or 3; The compounds of formula I have been found to have good affinity for the minor amine related receptors (TAAR), particularly TAAR1. The compounds are useful for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological disorders such as Parkinson's disease, For the treatment of migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, energy expenditure and assimilation disorders, body temperature homeostatic and dysfunctions, sleep and circadian rhythm disorders, and cardiovascular disorders Can be used. |