| abstract |
The compounds of formulas Ia-d, and their stereoisomers, geometric isomers, tautomers, solvates, metabolites, and pharmaceutically acceptable salts, can be used to modulate the activity of lipid kinases, including PI3K, It is useful for the treatment of the same disease. Disclosed are methods of using compounds of formula Ia-d for the in vitro, in vitro and in vivo diagnosis, prevention or treatment of the aforementioned diseases or related pathological conditions in mammalian cells.n n n <Formula I>n n n n n n n n ≪ EMI ID =n n n n n n n n Wherein X is S or O, mor is a morpholine group, and R 3 is a monocyclic heteroaryl group.n n n Phosphoinositide 3-kinase inhibitor compound |