| abstract |
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments that are specific for TNF alpha and that contain specific light and heavy sequences that are optimized for stability, solubility, in vitro and in vivo binding to TNFa, and low immunogenicity . The antibody is designed for the diagnosis and / or treatment of TNFa-related disorders. Nucleic acids, vectors and host cells for recombinant antibody expression of the invention, methods for their isolation, and uses of said antibodies in medicaments are also disclosed.n n n TNFa, scFv antibody, Fab fragments, stability, solubility |