| abstract |
The present invention relates to an astrocyte-specific drug carrier comprising a retinoid derivative and / or a vitamin A analog as a constituent, a drug delivery method using the drug carrier, a medicament containing the same, and a therapeutic method using the medicament. By binding or incorporating a retinoid derivative such as vitamin A or a vitamin A analog into the drug carrier, it becomes possible to carry out the therapeutic drug specifically to the astrocytic cells, thereby suppressing astrocytic cell disease efficiently and effectively with minimal side effects Or prevention. As a drug that controls the activity or proliferation of astrocytes, for example, siRNA against HSP47, which is a collagen-specific molecular chaperone, is enclosed in the drug carrier to inhibit the secretion of collagen type I to IV at the same time, Can be effectively suppressed. |