| abstract |
The peptide mimetics of the template-fixed beta-hairpin structure represented by formula (I) of the present invention and salts thereof have the properties of inhibiting proteases, in particular serine proteases, in particular cathepsin G, elastase or tryptase: In formula I, Z is a chain of 11 alpha-amino acid residues, wherein the amino acid is Gly, Phe or Pro (4NHCOPhe) according to the position in the chain, or as the remainder of the above formula, Type residues. Such a peptide mimetic of the? -Airpin structure can be produced by a method based on solid-phase and liquid-phase hybrid synthesis methods. |