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grantDate 2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-101428514-B1
titleOfInvention Hybrid manufacturing method using electrospinning and lyophilization for the production of aggregate bioactive cell supports
abstract The present invention relates to a hybrid manufacturing method using electrospinning and lyophilization for the production of an aggregate cell support. Conventional aggregate biomedical scaffolds have disadvantages in that they can not withstand compressive forces due to contraction of the muscles of the corresponding region. However, the present invention provides a technique for producing an aggregate production guiding support by mixing silk fibroin and hydroxyapatite particles. The aggregate production guiding support according to the present invention has a three-dimensional porous structure or a fibrous structure, has high biodegradability, It has a compressive resistance against the contraction force of muscle in vivo and has an advantage of inducing bone formation by excellent mechanical properties that can control the compression resistance according to the content of hydroxyapatite.
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