http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101428506-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 |
| filingDate | 2005-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101428506-B1 |
| titleOfInvention | 2,4 (4,6) pyrimidine derivatives |
| abstract | The present invention relates to compounds of formula (I), the N-oxide forms thereof, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof:n n n n n n n n In this formula,n n n Z 1 and Z 2 represent NH;n n n Y is -C 3-9 alkyl-; -C 3-9 alkenyl-; -C 1-5 alkyl-NR 6 -C 1-5 alkyl-; -C 1-5 alkyl-NR 7 -CO-C 1-5 alkyl-; C 1-6 alkyl-CO-NH-; -C 1-6 alkyl-NH-CO-; C 1-2 alkyl-CO-Het 10 -CO-; C 1-3 alkyl-NH-CO-Het 3 -; -Het 4 -C 1-3 alkyl-CO-NH-C 1-3 alkyl-; -C 1-2 alkyl-NH-CO-L 1 -NH-; -NH-CO-L 2 -NH-; -C 1-2 alkyl-CO-NH-L 3 -CO-; -C 1-2 alkyl-CO-NH-L 1 -NH-CO-C 1-3 alkyl-; -C 1-2 alkyl-CO-NH-L 3 -CO-NH-C 1-3 alkyl-; -C 1-2 alkyl-NR 11 -CH 2 -CO-NH-C 1-3 alkyl-; Het 5- CO-C 1-2 alkyl-; -C 1-5 alkyl-CO-NH-C 1-3 alkyl-CO-NH-; -C 1-5 alkyl-NR 13 -CO-C 1-3 alkyl-NH-; -C 1-3 alkyl-NH-CO-Het 27 -CO- or C 1-3 alkyl-CO-Het 28 -CO-NH-;n n n X 1 is a direct bond, O, -OC 1-2 alkyl-, -CO-C 1-2 alkyl-, -NR 16 -C 1-2 alkyl-, CO-NR 17 -, Het 23 -C 1-2 Alkyl- or C 1-2 alkyl;n n n X 2 is a direct bond, O, -OC 1-2 alkyl-, -CO-C 1-2 alkyl-, -NR 18 -C 1-2 alkyl-, CO-NR 19 -, Het 24 -C 1-2 Alkyl- or C 1-2 alkyl;n n n R 1 and R 5 each independently represent hydrogen, halo, C 1-6 alkyloxy- or C 1-6 alkoxy substituted by Het 1 or C 1-4 alkyloxy-;n n n R 2 and R 4 each independently represent hydrogen or halo;n n n R 3 represents hydrogen or cyano;n n n R 6 , R 7 , R 13 , R 17 and R 19 represent hydrogen;n n n R 11 represents hydrogen or C 1-4 alkyl;n n n R 16 and R 18 represent hydrogen, C 1-4 alkyl or Het 17 -C 1-4 alkyl-;n n n L 1, L 2 and L 3 are each independently selected from phenyl, methyl sulfide, cyano, a poly C 1-4 alkylphenyl, C 1-4 alkyloxycarbonyl to, pyridinyl, mono- or di (C 1-4 alkyl ) Amino and C 3-6 cycloalkyl; and C 1-8 alkyl optionally substituted by one or more substituents, if desired,n n n Het 1 , Het 2 and Het 17 each independently represent morpholinyl, oxazolyl, isoxazolyl or piperazinyl;n n n Het 3 , Het 4 and Het 5 each independently represent morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl;n n n Het 10 represents piperazinyl, piperidinyl, pyrrolidinyl or azetidinyl;n n n Het 22 represents morpholinyl, oxazolyl, isoxazolyl or piperazinyl, wherein Het 22 is optionally substituted by C 1-4 alkyl;n n n Het 23 and Het 24 each independently represent a heterocycle selected from pyrrolidinyl, piperazinyl and piperidinyl, wherein Het 23 and Het 24 are optionally substituted by a Het 22 -carbonyl substituent;n n n Het 27 and Het 28 each independently represent a heterocycle selected from morpholinyl, piperazinyl, piperidinyl and pyrrolidinyl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023113510-A1 |
| priorityDate | 2004-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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