http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101427291-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 |
| filingDate | 2012-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101427291-B1 |
| titleOfInvention | Pharmaceutical composition for reversing multidrug resistance comprising alkoxyphenylpropenone derivatives or pharmaceutically acceptable salts thereof as an active ingredient |
| abstract | The present invention relates to an alkoxyphenylpropenone derivative or a pharmaceutically acceptable salt thereof, which exhibits an inhibitory action on P-glycoprotein activity, and a pharmaceutical composition for inhibiting multidrug resistance, which comprises the same as an active ingredient. The compound according to the present invention increases the absorption of a drug for oral administration (anti-cancer drug) to increase the anticancer efficacy, thereby making it possible to exhibit an excellent effect even at a low dose. It inhibits P-glycoprotein (P-gp) Inhibits the release of the anticancer drug, thereby increasing the accumulation of the anticancer drug into cancer cells. In addition, it can be effectively used as a pharmaceutical composition for inhibiting multidrug resistance by minimizing the drug excreted into the cell, It is possible to increase the absolute bioavailability of the drug by increasing the absorption of the drug dose-dependently when the combination is administered, thereby increasing the anticancer efficacy by enhancing drug accumulation into the cancer cell, and thus it can be usefully used as a pharmaceutical composition for anticancer drug. |
| priorityDate | 2012-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 165.