| abstract |
The present invention relates to a stable metastin having excellent biological activity (cancer metastasis inhibitory activity, cancer growth inhibitory activity, gonadotropin secretion stimulating activity, sex hormone secretion stimulating activity, gonadotropin secretion inhibiting activity, sex hormone secretion inhibiting activity, etc.) Lt; / RTI > By replacing the constituent amino acids of the metastin with specific amino acids, the metastin derivatives of the present invention are further improved in blood stability, solubility and the like, have a reduced gelation tendency, have improved pharmacokinetics, Inhibitory activity. The metastin derivatives of the present invention also have gonadotropin secretion inhibitory activity, sex hormone secretion inhibitory activity and the like. |