| abstract |
The present invention relates to a sustained-release microparticle containing a water-insoluble drug and a preparation method thereof, and more particularly to a water-insoluble drug and a polyvalent metal cation salt of a polylactic acid or a derivative thereof containing at least one carboxyl group at the terminal And the water-insoluble drug is trapped in the polyvalent metal cation salt of the polylactic acid or a derivative thereof, so that a constant release rate and an effective blood concentration can be continuously maintained without abrupt initial over-discharge and delayed release of the drug, To a microparticle which can be usefully used as a long-term sustained-release preparation, and a method for producing the same. |