| abstract |
A method of producing a solid dispersion of an active ingredient comprising feeding an active ingredient and a matrix forming agent to an extruder to form a uniform extrudate, the extruder comprising two or more rotating shafts (2) The shaft 2 has a plurality of processing members that are axially arranged and arranged such that (i) the supply and delivery portion A, (ii) one or more mixing portions B, and (iii) The processing member defining the portion E and defining the mixing portion B comprises a mixing member 11, 12, 13 derived from a screw type member (FIG. 2). |