| abstract |
The present invention relates to novel compounds of formula I wherein R 1 , R 12 , L, X and Y are as defined herein and their pharmaceutically acceptable salts, their preparation, compositions containing them and Their therapeutic uses are disclosed. The compounds are inhibitors of the enzyme MPO and are therefore particularly useful for the treatment or prevention of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders. [Index] Pyrrolo [3,2-d] pyrimidin-4-one derivatives, enzyme MPO, neuroinflammatory disorders |